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Sarkar, Sahotra. Cut-and-paste genetics: a CRISPR revolution / Sahotra Sarkar. — 1 online resource (xvii, 205 pages) : illustrations — <URL:http://elib.fa.ru/ebsco/2985800.pdf>.Record create date: 4/1/2021 Subject: Gene editing.; Gene editing — Moral and ethical aspects.; CRISPR-associated protein 9.; Gene Editing — ethics.; CRISPR-Cas Systems.; Clustered Regularly Interspaced Short Palindromic Repeats.; CRISPR-Associated Protein 9.; Gene Editing — history.; Genetic Diseases, Inborn — therapy.; CRISPR-associated protein 9.; Gene editing. Collections: EBSCO Allowed Actions: –
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"Bringing together historical and ethical insights on the revolutionary, Nobel prize winning CRISPR/Cas9 gene editing technology, this accessible book examines the history of human attempts to understand and control our evolution, how the CRISPR/Cas9 technology works and what it could mean for the elimination of genetic diseases"--.
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Table of Contents
- Cover
- Half Title
- Title Page
- Copyright Page
- Dedication
- Contents
- Preface
- Chapter 1: Breeding a Perfect Society
- Beginnings: Davenport and Eugenics in the United States
- IQ and Involuntary Sterlilization
- Genetics against Eugenics
- Exporting Sterlization
- The Watson Scandal
- Establishing Human Genetics
- Davenport’s Dreams Today
- Chapter 2: Molecular Diseases, Elusive Treatments
- The Molecularization of Biology
- Molecular Diseases
- But No Molecular Medicine
- Dreams of Editing Genes
- Followed by Stunning Failure
- Recombinant DNA Made No Difference
- Gene Editing BC (before CRISPR)
- Chapter 3: What Good Was the Human Genome Project?
- The Sequence Revealed
- Common Diseases and Common Variants
- Medical Irrelevance of the Sequence
- Critiques of the HGP, Past and Present
- Evolution and Architecture of the Genome
- Evolutionary Contingency
- Chapter 4: The CRISPR Revolution
- The CRISPR Structure Emerges
- Its Function Is Decoded
- The Mechanism of Immunity
- Onward to Gene Editing
- The Delivery Problem
- Ubiquitous CRISPR
- Chapter 5: Inevitable Eugenics?
- Eugenics in the News
- What Is Eugenics?
- Defining Eugenics
- A Working Definition
- Inescapable Eugenics?
- Matters of Ethics
- Chapter 6: The Elimination of Genetic Diseases
- The Long Reach of Huntington’s Disease
- The He Jiankui Affair
- The Ethics of Human Germline Intervention
- The Limits of Current Science
- Gene Specificity and Lenin’s Brain
- A Policy Proposal
- Proceed with Caution
- Liberal and Moderate Eugenics
- Chapter 7: Designer Baby Delusions
- Why Not Genetic Enhancement?
- The Normal and the Enhanced
- Liberal Eugenics and Genetic Enhancement
- Rationality of Genetic Enhancement
- Planned Human Obsolsescence
- Where Is the Science? The Case of Intelligence
- Genomics and IQ
- What about Physical Traits?
- Genetic Reductionism
- Contextual Developmental Construction
- What Is Perfection?
- Chapter 8: A CRISPR Future
- Editing the Human Germline
- Gene Drives
- The Ethics of Promoting Extinction
- Biosecurity
- CRISPR without the Hype
- Notes
- PREFACE
- CHAPTER 1
- CHAPTER 2
- CHAPTER 3
- CHAPTER 4
- CHAPTER 5
- CHAPTER 6
- CHAPTER 7
- CHAPTER 8
- References
- Index
- About the Author
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